Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043707 | 1.00 | MAPT (0.62) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9042678 | 0.98 | MAPT (0.64) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9044525 | 0.95 | MAPT (0.64) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9044510 | 0.94 | MAPT (0.71) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9043656 | 0.89 | MAPT (0.65) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9041291 | 0.89 | MAPT (0.65) | MAPTRAB9APKML3MBTL1PARP10 | |
| SCHEMBL9040101 | 0.88 | PLA2G4B (0.60) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9042116 | 0.87 | MAPT (0.57) | MAPTRAB9AHDAC1HDAC2HDAC3 | |
| SCHEMBL9041763 | 0.87 | MAPT (0.67) | MAPTRAB9APKMGAATSHR | |
| SCHEMBL9044252 | 0.87 | FFAR1 (0.58) | MAPTRAB9APLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |