Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | SNCA | P37840 | 2/20 | 0.51 |
| ▸ | CTRC | Q99895 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324445 | 0.80 | RAF1 (0.47) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8319684 | 0.79 | CHEK1 (0.50) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8321242 | 0.78 | MAPT (0.65) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8322866 | 0.77 | NPC1 (0.66) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8331764 | 0.76 | RAF1 (0.52) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL9045821 | 0.75 | RAF1 (0.51) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8319627 | 0.74 | NTRK1 (0.62) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL8319989 | 0.74 | NTRK1 (0.47) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL5790646 | 0.73 | NTRK1 (0.67) | RAF1NTRK1MAPTAPPSNCA | |
| SCHEMBL12537519 | 0.73 | NTRK1 (0.67) | RAF1NTRK1MAPTAPPSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | claimed |