Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318368 | 0.88 | RAF1 (0.46) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8319991 | 0.88 | RAF1 (0.48) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8323550 | 0.83 | RAF1 (0.49) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8321195 | 0.83 | RAF1 (0.47) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8322980 | 0.82 | RAF1 (0.46) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8320797 | 0.82 | CTRC (0.48) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8324301 | 0.81 | RAF1 (0.46) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL9044277 | 0.80 | RAF1 (0.56) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8320639 | 0.80 | NTRK1 (0.46) | RAF1NTRK1CTRCAPPMAPT | |
| SCHEMBL8318608 | 0.79 | RAF1 (0.43) | RAF1NTRK1CTRCAPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | claimed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | claimed |
| EP-0741726-B1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN SPA (IT) | 1999-11-17 | — | — | EP | disclosed |
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |
| EP-0741726-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-11-13 | — | — | EP | disclosed |
| WO-1996016964-A1 | SUBSTITUTED 3-ARYLIDENE-7-AZAOXINDOLE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A (IT) | 1996-06-06 | — | — | WO | disclosed |