Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 10/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10921936 | 0.99 | TBXA2R (0.44) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL7516230 | 0.87 | TBXA2R (0.46) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL10918266 | 0.86 | TBXA2R (0.46) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL9377375 | 0.85 | TBXA2R (0.45) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL10921827 | 0.84 | TBXA2R (0.56) | TBXA2RTBXAS1 | |
| SCHEMBL8797046 | 0.84 | TBXA2R (0.46) | TBXA2RTBXAS1ALOX5 | |
| Hydrochloric Acid SCHEMBL10960982 | 0.83 | TBXA2R (0.55) | TBXA2RTBXAS1 | |
| SCHEMBL10918833 | 0.83 | TBXA2R (0.53) | TBXA2RTBXAS1 | |
| SCHEMBL8798040 | 0.83 | TBXA2R (0.43) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL10922645 | 0.82 | TBXAS1 (0.45) | TBXA2RTBXAS1ALOX5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345747-B1 | Tricyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 1996-06-26 | — | — | EP | disclosed |
| US-5302596-A | DIBENZO-CYCLOHEPTENES,-OXEPINS AND-THIEPINS SUBSTITUTED BY A HETEROCYCLO-ALKYL | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-04-12 | — | — | US | disclosed |
| US-5242931-A | Antiischemic agents and cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5118701-A | Antiischemic agents, anticoagulants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4999363-A | Inhibit biosynthesis of thromboxane A2 | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-03-12 | — | — | US | disclosed |
| EP-0345747-A2 | Tricyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-13 | — | — | EP | disclosed |