SCHEMBL9044394

SCHEMBL9044394

O=C(CBr)N1CCN(c2ccccc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.70
NPSR1 Q6W5P4 2/20 0.70
LMNA P02545 1/20 0.70
ALDH1A1 P00352 4/20 0.68
HTR1A P08908 2/20 0.64
HTR7 P34969 2/20 0.64
SMN1; SMN2 Q16637 4/20 0.62
HPGD P15428 1/20 0.62
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
GRM5 P41594 1/20 0.59
GFER P55789 1/20 0.59
ATM Q13315 1/20 0.59
GAA P10253 1/20 0.59
USP2 O75604 1/20 0.59
TSHR P16473 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30528252 0.85 MAPT (0.86) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL7840682 0.84 MAPT (0.72) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL7561191 0.83 AKR1C3 (0.68) MAPTLMNAALDH1A1HTR1AHTR7
SCHEMBL3299369 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL8245954 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL5245371 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL17834330 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL6388426 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL12781874 0.82 MAPT (0.70) MAPTNPSR1LMNAALDH1A1HTR1A
SCHEMBL11256236 0.81 MAPT (0.82) MAPTNPSR1LMNAALDH1A1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0512352-B1 Substituted carboxylic acid derivatives HOFFMANN LA ROCHE (CH) 1996-03-27 EP disclosed
US-5344843-A Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders HOFFMAN-LA ROCHE INC. (US) 1994-09-06 US disclosed
EP-0512352-A2 Substituted carboxylic acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1992-11-11 EP disclosed