Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | HTR7 | P34969 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17834330 | 0.87 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL30528252 | 0.87 | MAPT (0.86) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL3299369 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL5245371 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL6388426 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL12781874 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL8245954 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL9044394 | 0.84 | MAPT (0.70) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL28135156 | 0.82 | MAPT (0.78) | MAPTLMNANPSR1ALDH1A1HTR1A | |
| SCHEMBL6706289 | 0.82 | ME2 (0.82) | MAPTLMNANPSR1ALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |