Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | PTPRC | P08575 | 4/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.69 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPRF | P10586 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043928 | 0.95 | PKM (0.66) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9046005 | 0.95 | PKM (0.66) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9042971 | 0.94 | PTPRC (0.67) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9042067 | 0.94 | PTPRC (0.67) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9043540 | 0.94 | PTPRC (0.69) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9041063 | 0.93 | PTPRC (0.65) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9042501 | 0.93 | PTPRC (0.65) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9402815 | 0.93 | PTPRC (0.65) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9042859 | 0.93 | PTPRC (0.65) | PKMPTPRCPTPN1PARP10MAPT | |
| SCHEMBL9043699 | 0.93 | PTPRC (0.65) | PKMPTPRCPTPN1PARP10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | claimed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | claimed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | claimed |
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |