Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535416 | 0.95 | PIM1 (0.48) | PTPN11HRH3PIM1CYP1A2HSD17B10 | |
| Hydrochloric Acid SCHEMBL9689129 | 0.93 | PIM1 (0.47) | PTPN11HRH3PIM1CYP1A2HSD17B10 | |
| SCHEMBL9689165 | 0.92 | MKNK1 (0.45) | PTPN11MKNK1BRD4ATAD2 | |
| Hydrochloric Acid SCHEMBL9688928 | 0.90 | MKNK1 (0.44) | PTPN11MKNK1BRD4ATAD2 | |
| Bromide SCHEMBL9689909 | 0.90 | MKNK1 (0.44) | PTPN11MKNK1BRD4ATAD2 | |
| Hydrochloric Acid SCHEMBL9690717 | 0.90 | MKNK1 (0.44) | PTPN11MKNK1BRD4ATAD2 | |
| Citric Acid SCHEMBL9043866 | 0.83 | PTPN11 (0.40) | PTPN11HRH3CYP1A2HSD17B10USP2 | |
| SCHEMBL9534992 | 0.82 | CDC7 (0.54) | HRH3PIM1CDC7DBF4BRD4 | |
| Hydrochloric Acid SCHEMBL9535340 | 0.81 | CDC7 (0.53) | HRH3PIM1CDC7DBF4BRD4 | |
| SCHEMBL382481 | 0.79 | JAK1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0464927-B1 | 3-[(5-Methyl-2-furanyl)methyl]-N-(4-piperidinyl)-3H-imidazo[4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate | JANSSEN PHARMACEUTICA NV (BE) | 1996-09-04 | — | — | EP | claimed |
| EP-0232937-B1 | ANTI-HISTAMINIC COMPOSITIONS CONTAINING N-HETEROCYCLYL-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-19 | — | — | EP | claimed |
| EP-0464927-B1 | 3-[(5-Methyl-2-furanyl)methyl]-N-(4-piperidinyl)-3H-imidazo[4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate | JANSSEN PHARMACEUTICA NV (BE) | 1996-09-04 | — | — | EP | disclosed |
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| EP-0232937-B1 | ANTI-HISTAMINIC COMPOSITIONS CONTAINING N-HETEROCYCLYL-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-19 | — | — | EP | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |