Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046763 | 0.92 | EGFR (0.55) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL9045184 | 0.89 | EGFR (0.47) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL25720396 | 0.89 | EGFR (0.47) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL24054537 | 0.89 | AHR (0.47) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL9047155 | 0.89 | MEN1 (0.56) | EGFRSRCTOP2AMEN1KMT2A | |
| SCHEMBL9045464 | 0.89 | HIF1A (0.55) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL9043908 | 0.87 | MAPT (0.49) | EGFRSRCTOP2AMEN1KMT2A | |
| SCHEMBL9046474 | 0.86 | TP53 (0.53) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL9046189 | 0.85 | HTT (0.55) | EGFRSRCTOP2AFEN1MEN1 | |
| SCHEMBL9045854 | 0.85 | KCNQ3 (0.48) | EGFRSRCTOP2AFEN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452873-B1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5126341-A | Treatment of rheumarthritis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0452873-A1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |