Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046763 | 0.92 | EGFR (0.55) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL9045184 | 0.89 | EGFR (0.47) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL25720396 | 0.89 | EGFR (0.47) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL9044503 | 0.89 | TYMS (0.48) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL24054537 | 0.89 | AHR (0.47) | MEN1KMT2AEGFRSRCMAPT | |
| SCHEMBL9045464 | 0.89 | HIF1A (0.55) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL9043908 | 0.89 | MAPT (0.49) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL9044475 | 0.89 | MEN1 (0.59) | MEN1KMT2ANPC1EGFRSRC | |
| SCHEMBL9044545 | 0.86 | KDM4E (0.57) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL9046474 | 0.86 | TP53 (0.53) | MEN1KMT2ANPC1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452873-B1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5126341-A | Treatment of rheumarthritis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0452873-A1 | 1,8-Naphthyridin-2-one derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |