Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4449565 | 0.95 | — | — | |
| Bicarbonate SCHEMBL209657 | 0.95 | CA4 (0.55) | — | |
| Bicarbonate SCHEMBL15662076 | 0.90 | CA4 (0.50) | — | |
| Bicarbonate SCHEMBL2257748 | 0.90 | — | — | |
| Bicarbonate SCHEMBL15662074 | 0.90 | CA4 (0.50) | — | |
| Bicarbonate SCHEMBL28231622 | 0.90 | CA4 (0.39) | — | |
| Bicarbonate SCHEMBL11321204 | 0.90 | — | — | |
| Bicarbonate SCHEMBL8799118 | 0.90 | — | — | |
| Bicarbonate SCHEMBL2558186 | 0.89 | CA4 (0.60) | — | |
| Bicarbonate SCHEMBL2420 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420237-B1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | EISAI CO LTD (JP) | 1996-03-06 | — | — | EP | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |