Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044510 | 0.92 | MAPT (0.71) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9041763 | 0.89 | MAPT (0.67) | MAPTRAB9APKMALDH1A1PARP10 | |
| SCHEMBL9041291 | 0.88 | MAPT (0.65) | MAPTRAB9APKMKMT2APARP10 | |
| SCHEMBL9043656 | 0.88 | MAPT (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9042678 | 0.88 | MAPT (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9044525 | 0.88 | MAPT (0.64) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6191009 | 0.87 | SMN1; SMN2 (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9044226 | 0.86 | MAPT (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9043707 | 0.86 | MAPT (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9044042 | 0.84 | PTPRC (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |