Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.66 |
| ▸ | EDNRB | P24530 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045035 | 0.89 | EDNRA (0.61) | EDNRAEDNRBGAAKMT2A | |
| SCHEMBL9045463 | 0.89 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL9047114 | 0.87 | EDNRA (0.82) | EDNRAEDNRBPIK3CG | |
| SCHEMBL9046198 | 0.84 | KMT2A (0.55) | EDNRAEDNRBGAAKMT2APTGDR2 | |
| SCHEMBL9045999 | 0.84 | EDNRA (0.85) | EDNRAEDNRB | |
| SCHEMBL9046873 | 0.80 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL9053901 | 0.79 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL9046624 | 0.78 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL9044668 | 0.78 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL9045783 | 0.78 | EDNRA (0.78) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | claimed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | claimed |
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |