Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.61 |
| ▸ | EDNRB | P24530 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044704 | 0.89 | EDNRA (0.66) | EDNRAEDNRBKMT2AGAA | |
| SCHEMBL9045463 | 0.89 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL9044490 | 0.85 | EDNRA (0.45) | EDNRAEDNRBKMT2AMEN1TSHR | |
| SCHEMBL9045435 | 0.84 | EDNRA (0.60) | EDNRAEDNRBKMT2AMEN1TSHR | |
| SCHEMBL9045531 | 0.80 | EDNRA (0.64) | EDNRAEDNRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL9045999 | 0.80 | EDNRA (0.85) | EDNRAEDNRB | |
| SCHEMBL9052960 | 0.79 | EDNRA (0.60) | EDNRAEDNRBKMT2AMEN1TSHR | |
| SCHEMBL9045073 | 0.79 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL9046616 | 0.77 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL9044684 | 0.77 | EDNRA (0.59) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | claimed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | claimed |
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |