Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.50 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29721807 | 1.00 | TSHR (0.56) | TSHRCYP3A4GRIK1GRIA1GRIA2 | |
| SCHEMBL30657595 | 0.86 | TSHR (0.56) | TSHRCYP3A4GRIK1GRIA1GRIA2 | |
| SCHEMBL29126950 | 0.86 | TSHR (0.56) | TSHRCYP3A4GRIK1GRIA1GRIA2 | |
| SCHEMBL6677996 | 0.81 | GAA (0.57) | TSHRGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL995544 | 0.80 | GRIK1 (0.56) | TSHRCYP3A4GRIK1GRIA1GRIA2 | |
| SCHEMBL6563795 | 0.79 | ESR1 (0.59) | TSHRGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL11824811 | 0.79 | MAPK1 (0.59) | TSHRGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL20816305 | 0.79 | TDP1 (0.50) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29126960 | 0.79 | GRIK1 (0.50) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL30657601 | 0.79 | ESR1 (0.59) | TSHRGRIK1GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677708-B | Pyrrolo-quinoxaline Process for the preparation of a pinine | 深圳万知达企业管理有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-114656486-B | Purinone compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-115322200-B | Preparation method of spiro pyrroloquinoxaline derivative | 五邑大学 | 2023-09-19 | — | — | CN | disclosed |
| CN-115677708-A | Preparation method of pyrroloquinoxaline | 五邑大学 | 2023-02-03 | — | — | CN | disclosed |
| CN-115322200-A | Preparation method of spiro pyrroloquinoxaline derivative | 五邑大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-114656486-A | Purine ketone compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-06-24 | — | — | CN | disclosed |
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| CN-1059723-A | Hete rocyclic derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-03-25 | — | — | CN | disclosed |
| US-3939159-A | ANTICONVULSANT, CNS DEPRESSANT | AMERICAN HOECHST CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |