Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 15/20 | 0.82 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044573 | 0.92 | ALOX5AP (0.71) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9045553 | 0.92 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9046406 | 0.91 | ALOX5AP (0.78) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL2108478 | 0.84 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9584575 | 0.83 | ALOX5AP (0.80) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9178666 | 0.83 | ALOX5AP (0.76) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL169405 | 0.82 | ALOX5AP (0.84) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9140363 | 0.82 | ALOX5AP (0.62) | ALOX5APALOX5CYP3A4CYP2C9PTGS2 | |
| SCHEMBL2106671 | 0.81 | ALOX5AP (0.89) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL3092549 | 0.81 | ALOX5AP (0.82) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7215966-A | — | — | None | — | — | JP | disclosed |
| EP-0535925-B1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC (CA) | 1996-04-24 | — | — | EP | disclosed |
| JP-H07215966-A | (BICYCLIC-HETERO-ARYLMETHOXY)INDOLE AS INHIBITOR OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC | 1995-08-15 | — | — | JP | disclosed |
| US-5308850-A | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0535925-A1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |