Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 13/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.67 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.65 |
| ▸ | PTGES | O14684 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176433 | 0.86 | ALOX5AP (1.00) | ALOX5APALOX5PTGES2PTGESCYP3A4 | |
| SCHEMBL2108478 | 0.86 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL2106671 | 0.85 | ALOX5AP (0.89) | ALOX5APALOX5PTGES2CYP3A4CYP2C9 | |
| SCHEMBL9584575 | 0.84 | ALOX5AP (0.80) | ALOX5APALOX5PTGES2PTGESCYP3A4 | |
| SCHEMBL2108140 | 0.84 | ALOX5AP (0.84) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL9044799 | 0.83 | ALOX5AP (0.82) | ALOX5APALOX5PTGES2PTGESCYP3A4 | |
| SCHEMBL9434427 | 0.81 | ALOX5AP (0.87) | ALOX5APALOX5PTGES2PTGESCYP3A4 | |
| SCHEMBL9736625 | 0.81 | PTGES2 (0.71) | ALOX5APALOX5PTGES2PTGESCYP3A4 | |
| SCHEMBL9305688 | 0.80 | ALOX5AP (1.00) | ALOX5APALOX5CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2108502 | 0.80 | PTGS1 (0.80) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389650-A | Antiinflammatory agents, anticoagulants, antispasmodic agents | MERCK FROSST CANADA, INC. (CA) | 1995-02-14 | — | — | US | disclosed |
| EP-0535923-A1 | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |