Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047672 | 0.90 | EDNRA (0.53) | EDNRAEDNRBGAAMEN1KMT2A | |
| SCHEMBL9045300 | 0.89 | EDNRA (0.58) | EDNRAALDH1A1POLBEDNRBHPGD | |
| SCHEMBL9047103 | 0.87 | EDNRA (0.56) | EDNRAALDH1A1EDNRBHPGDGAA | |
| SCHEMBL9045584 | 0.86 | EDNRA (0.73) | EDNRAALDH1A1EDNRB | |
| SCHEMBL9492514 | 0.85 | EDNRA (0.54) | EDNRAEDNRBGAAMEN1KMT2A | |
| SCHEMBL9044456 | 0.85 | EDNRA (0.61) | EDNRAEDNRBMEN1KMT2AALOX15 | |
| SCHEMBL9045783 | 0.84 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL9044505 | 0.83 | ALDH1A1 (0.44) | EDNRAALDH1A1TSHRPOLBEDNRB | |
| SCHEMBL9044533 | 0.77 | EDNRA (0.40) | EDNRAALDH1A1TSHRPOLBEDNRB | |
| SCHEMBL9046333 | 0.76 | MAPT (0.45) | EDNRAALDH1A1HPGDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |