Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275517 | 0.79 | NPC1 (0.59) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL10282498 | 0.78 | NPC1 (0.57) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL10262049 | 0.74 | CA12 (0.66) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL18483394 | 0.74 | NPC1 (0.57) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL10332321 | 0.74 | NPC1 (0.62) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL425164 | 0.74 | NPC1 (0.68) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL180384 | 0.73 | NPC1 (0.73) | NPC1RAB9ACA12CA9MGLL | |
| SCHEMBL11275127 | 0.72 | LMNA (0.58) | NPC1RAB9ACA12CA9TSHR | |
| SCHEMBL3095761 | 0.71 | NPC1 (0.70) | NPC1RAB9ACA12CA9MGLL | |
| Hydrochloric Acid SCHEMBL11786759 | 0.71 | NPC1 (0.70) | NPC1RAB9ACA12CA9MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731795-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |