Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.76 |
| ▸ | EDNRB | P24530 | 9/20 | 0.76 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046653 | 0.93 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL9045018 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL9044584 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL9045132 | 0.86 | EDNRA (0.98) | EDNRAEDNRB | |
| SCHEMBL9046446 | 0.86 | EDNRA (0.84) | EDNRAEDNRB | |
| SCHEMBL9493637 | 0.85 | EDNRA (0.79) | EDNRAEDNRB | |
| SCHEMBL9493305 | 0.84 | MCL1 (0.53) | EDNRAEDNRBMCL1ALDH1A1LMNA | |
| SCHEMBL9044922 | 0.83 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL9046193 | 0.83 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL9044911 | 0.83 | EDNRA (0.76) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | claimed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |