Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.80 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.68 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.61 |
| ▸ | PTPRC | P08575 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421067 | 0.89 | GPBAR1 (1.00) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9581618 | 0.88 | GPBAR1 (0.97) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9129064 | 0.88 | GPBAR1 (0.82) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9581634 | 0.88 | GPBAR1 (0.97) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7599570 | 0.87 | GPBAR1 (0.82) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9043601 | 0.86 | GPBAR1 (0.70) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL26632676 | 0.85 | GPBAR1 (0.92) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL3271764 | 0.85 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL3270032 | 0.85 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9130161 | 0.85 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512352-B1 | Substituted carboxylic acid derivatives | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5344843-A | Carnitine acryltransferase enzyme inhibitors as antiischemic agents and for cardiovascular disorders | HOFFMAN-LA ROCHE INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0512352-A2 | Substituted carboxylic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-11 | — | — | EP | disclosed |