Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.77 |
| ▸ | EDNRB | P24530 | 6/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044617 | 0.94 | EDNRA (0.77) | EDNRAEDNRBTP53 | |
| SCHEMBL9043994 | 0.88 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL9044669 | 0.86 | EDNRA (0.84) | EDNRAEDNRB | |
| SCHEMBL9044945 | 0.85 | EDNRA (0.89) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL9494264 | 0.85 | ALDH1A1 (0.55) | EDNRAEDNRBALDH1A1TP53LMNA | |
| SCHEMBL9046379 | 0.84 | EDNRA (0.91) | EDNRAEDNRB | |
| SCHEMBL9045266 | 0.83 | EDNRA (0.79) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL9045370 | 0.83 | EDNRA (0.86) | EDNRAEDNRB | |
| SCHEMBL9044786 | 0.83 | EDNRA (0.89) | EDNRAEDNRB | |
| SCHEMBL9043529 | 0.83 | EDNRA (0.89) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | claimed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | claimed |
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |