Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045280 | 0.85 | KDM4E (0.41) | POLBALDH1A1HPGDMAPT | |
| SCHEMBL9042061 | 0.84 | KMT2A (0.48) | POLBALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8994407 | 0.81 | POLB (0.55) | POLBVNN1ALDH1A1NT5EPARP1 | |
| SCHEMBL7370711 | 0.74 | POLB (0.63) | POLBVNN1ALDH1A1PARP1NPC1 | |
| SCHEMBL7366799 | 0.71 | POLB (0.63) | POLBVNN1ALDH1A1PARP1NPC1 | |
| SCHEMBL186545 | 0.71 | PARP1 (0.68) | POLBPARP1SMN1; SMN2HPGDKCNK3 | |
| SCHEMBL29503529 | 0.71 | PARP1 (0.68) | POLBPARP1SMN1; SMN2HPGDKCNK3 | |
| SCHEMBL8736887 | 0.71 | KMT2A (0.62) | POLBVNN1ALDH1A1NT5EPARP1 | |
| SCHEMBL29941343 | 0.71 | KMT2A (0.62) | POLBVNN1ALDH1A1NT5EPARP1 | |
| SCHEMBL81347 | 0.69 | ATM (0.71) | POLBVNN1ALDH1A1PARP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0602097-B1 | TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1996-04-24 | — | — | EP | disclosed |
| EP-0602097-A1 | NEW TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION. | BOEHRINGER MANNHEIM GMBH (DE) | 1994-06-22 | — | — | EP | disclosed |
| WO-1993005047-A1 | NEW TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |