Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.76 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438420 | 0.86 | ALOX5 (1.00) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL8590069 | 0.86 | ALOX5 (1.00) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL1807930 | 0.86 | ALOX5 (1.00) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9047929 | 0.85 | ALOX5 (0.81) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9046462 | 0.84 | ALOX5 (0.77) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9047887 | 0.84 | ALOX5 (0.80) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9047578 | 0.83 | ALOX5 (0.72) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9047669 | 0.83 | ALOX5 (0.81) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049110 | 0.82 | ALOX5 (0.80) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049256 | 0.82 | ALOX5 (0.80) | ALOX5EPHX2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | claimed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |