SCHEMBL9047484

SCHEMBL9047484

COc1cc(C)c(C(=O)c2ccc(-c3ccccc3)cc2)cc1OC

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 1/20 0.51
ATM Q13315 1/20 0.51
MAPT P10636 5/20 0.51
CYP3A4 P08684 3/20 0.51
LMNA P02545 3/20 0.51
KDM4E B2RXH2 2/20 0.51
HSD17B10 Q99714 2/20 0.51
HPGD P15428 2/20 0.51
RECQL P46063 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.49
ALOX15 P16050 1/20 0.49
MAPK1 P28482 1/20 0.49
CYP1A2 P05177 2/20 0.48
CYP2C19 P33261 2/20 0.48
CYP2D6 P10635 1/20 0.48
HTT P42858 3/20 0.47
NPSR1 Q6W5P4 2/20 0.47
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7411516 0.84 TSHR (0.54) CDC25BATMMAPTCYP3A4LMNA
SCHEMBL7408146 0.81 GAA (0.53) CDC25BATMMAPTCYP3A4LMNA
SCHEMBL7438219 0.81 MAPT (0.67) MAPTCYP3A4LMNAKDM4EHSD17B10
SCHEMBL5494653 0.81 HPGD (0.57) MAPTCYP3A4LMNAHPGDSMN1; SMN2
SCHEMBL5484029 0.81 MAPT (0.50) MAPTCYP3A4LMNAKDM4EHSD17B10
SCHEMBL1010387 0.81 CYP1A2 (0.73) MAPTCYP3A4HPGDSMN1; SMN2CYP1A2
SCHEMBL7149910 0.80 HPGD (0.66) MAPTCYP3A4LMNAKDM4EHSD17B10
SCHEMBL11003498 0.79 KMT2A (0.49) CYP3A4LMNACYP1A2CYP2C19HTT
SCHEMBL3894224 0.79 MAPT (0.59) MAPTCYP3A4LMNAKDM4EHSD17B10
SCHEMBL4543074 0.78 MAPT (0.63) MAPTCYP3A4LMNAKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0339599-B1 Process for producing acylaromatic compounds SUMITOMO CHEMICAL CO (JP) 1996-08-21 EP disclosed
EP-0339599-A2 Process for producing acylaromatic compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-11-02 EP disclosed