Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611954 | 0.91 | MAPT (0.63) | TSHRMAPTMAPK1LMNAKDM4E | |
| SCHEMBL9047484 | 0.84 | CDC25B (0.51) | TSHRMAPTMAPK1POLBLMNA | |
| SCHEMBL7411615 | 0.83 | MAPT (0.51) | TSHRMAPTMAPK1POLBCYP3A4 | |
| SCHEMBL7410935 | 0.82 | POLB (0.62) | TSHRMAPTMAPK1POLBLMNA | |
| SCHEMBL6615739 | 0.82 | KMT2A (0.54) | TSHRMAPTMAPK1POLBLMNA | |
| SCHEMBL6617275 | 0.82 | TSHR (0.53) | TSHRMAPTMAPK1POLBKDM4E | |
| SCHEMBL4543074 | 0.81 | MAPT (0.63) | MAPTMAPK1LMNAKDM4EHSD17B10 | |
| SCHEMBL7407945 | 0.80 | TSHR (0.50) | TSHRMAPTMAPK1LMNAKDM4E | |
| SCHEMBL7410864 | 0.78 | RAB9A (0.49) | TSHRMAPTMAPK1LMNAKDM4E | |
| SCHEMBL7408146 | 0.78 | GAA (0.53) | MAPTMAPK1POLBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002088096-A1 | COMPOUNDS INHIBITING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES THEREOF | NEURO3D (FR) | 2002-11-07 | — | — | WO | disclosed |