Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.73 |
| ▸ | ACACB | O00763 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 12/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048294 | 0.89 | ALOX5 (0.66) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9046388 | 0.85 | ALOX5 (1.00) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9347884 | 0.82 | ALOX5 (0.67) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9051550 | 0.82 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9054917 | 0.82 | ALOX5 (0.77) | ALOX5EPHX2 | |
| SCHEMBL9079182 | 0.81 | ALOX5 (0.60) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9046903 | 0.81 | ALOX5 (0.74) | ALOX5EPHX2 | |
| SCHEMBL9048674 | 0.79 | ALOX5 (0.71) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9046473 | 0.79 | ALOX5 (0.75) | ALOX5ACACBEPHX2ACACA | |
| SCHEMBL9048902 | 0.78 | ALOX5 (0.74) | ALOX5ACACBEPHX2ACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | claimed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | claimed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | claimed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |