Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 16/20 | 0.60 |
| ▸ | HRH1 | P35367 | 16/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11747160 | 1.00 | HRH2 (0.60) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL27629332 | 0.98 | HRH2 (0.59) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL14670199 | 0.93 | HRH2 (0.56) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL15309235 | 0.88 | HRH2 (0.52) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL5540683 | 0.87 | HRH2 (0.51) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL27370873 | 0.86 | HRH2 (0.57) | HRH2HRH1 | |
| SCHEMBL9051052 | 0.85 | ALDH1A1 (0.56) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL11182660 | 0.85 | HRH2 (0.52) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL5542649 | 0.85 | HRH2 (0.52) | HRH2HRH1ALDH1A1POLBHTT | |
| SCHEMBL11392680 | 0.84 | HRH2 (0.55) | HRH2HRH1ALDH1A1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703908-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5461047-A | Analgesics and treats prostaglandin-E2 mediated diseases in animals | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| WO-1994029286-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5354747-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-10-11 | — | — | US | disclosed |
| US-4036828-A | 3,4-Bis(4-substituted piperazinyl)-3-cyclobutene-1,2-diones and related compounds | G. D. SEARLE & CO. (US) | 1977-07-19 | — | — | US | disclosed |