Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9976033 | 1.00 | MAPT (1.00) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL12490766 | 0.92 | RAB9A (0.85) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL9975998 | 0.87 | RAB9A (0.76) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL1249806 | 0.87 | RAB9A (0.76) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL15425120 | 0.86 | MAPT (0.76) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL17255200 | 0.79 | NPC1 (0.65) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL15425062 | 0.78 | KMT2A (0.70) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL6231163 | 0.78 | RAB9A (0.79) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL9976032 | 0.77 | MAPT (0.62) | MAPTMCL1RAB9AKMT2AMEN1 | |
| SCHEMBL6263733 | 0.76 | RAB9A (0.61) | MAPTMCL1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | claimed |