Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ramosetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 3/20 | 0.89 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 2/20 | 0.89 |
| ▸ | HTR3B known ✓ | O95264 | 2/20 | 0.89 |
| ▸ | HTR3D known ✓ | Q70Z44 | 2/20 | 0.89 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 2/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.89 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.89 |
| ▸ | HTR2B | P41595 | 1/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ramosetron SCHEMBL9052281 | 1.00 | HTR3A (0.89) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL1649718 | 0.94 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL9048400 | 0.94 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL3865249 | 0.94 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL8544326 | 0.93 | HTR3A (0.98) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL9052272 | 0.93 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL9048659 | 0.93 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL1171445 | 0.92 | HTR3A (0.96) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Fumaric Acid SCHEMBL9051288 | 0.87 | HTR3A (0.67) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Ramosetron SCHEMBL13531398 | 0.86 | HTR3A (0.84) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |