Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.71 |
| ▸ | HTR3B | O95264 | 1/20 | 0.71 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.71 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9051978 | 0.95 | HTR3A (0.64) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9048709 | 0.92 | HTR3A (0.60) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Fumaric Acid SCHEMBL9051968 | 0.87 | HTR3A (0.54) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9049402 | 0.86 | HTR3A (0.71) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9048622 | 0.85 | HTR3A (0.68) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| SCHEMBL9049208 | 0.85 | HTR3A (0.74) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Ramosetron SCHEMBL1649718 | 0.83 | HTR3A (1.00) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Ramosetron SCHEMBL9048400 | 0.83 | HTR3A (1.00) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Ramosetron SCHEMBL3865249 | 0.83 | HTR3A (1.00) | HTR3AADRA2AADRA2BADRA2CSLC6A4 | |
| Fumaric Acid SCHEMBL9048692 | 0.83 | HTR3A (0.65) | HTR3AADRA2AADRA2BADRA2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | claimed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | claimed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | claimed |