Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 4/20 | 0.56 |
| ▸ | MC4R | P32245 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | MC3R | P41968 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | MC1R | Q01726 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6008141 | 0.82 | MC5R (0.71) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL8089377 | 0.79 | MC5R (0.62) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL11445189 | 0.78 | MC5R (0.61) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL5551623 | 0.78 | MC5R (0.56) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL30054430 | 0.78 | CYP1A2 (0.59) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL30128850 | 0.78 | MC5R (0.56) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL1035887 | 0.78 | CYP1A2 (0.59) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL13607416 | 0.78 | MC5R (0.56) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| SCHEMBL4017226 | 0.77 | MC5R (0.65) | MC5RMC4RCYP1A2CYP2A6MC3R | |
| Hydrochloric Acid SCHEMBL6417293 | 0.77 | CYP1A2 (0.57) | MC5RMC4RCYP1A2CYP2A6MC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| US-5250565-A | Must incorporate a metabolically cleavable leaving group; pro-drugs; administering to mammals | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |
| EP-0416609-A2 | Benzo[b]thiophene-containing lipoxygenase-inhibiting compounds | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |