Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19770184 | 0.83 | ACHE (0.62) | ACHECCR3ABL1RIN1CXCR4 | |
| SCHEMBL7651915 | 0.83 | ACHE (0.62) | ACHECCR3ABL1RIN1CXCR4 | |
| SCHEMBL7952371 | 0.80 | ACHE (0.66) | ACHECCR3ABL1RIN1CXCR4 | |
| SCHEMBL2223627 | 0.80 | HTR2A (0.57) | ACHEHTR2ACCR3MAPK1ABL1 | |
| SCHEMBL7852368 | 0.79 | ACHE (0.64) | ACHECCR3ABL1RIN1 | |
| SCHEMBL12538992 | 0.78 | ACHE (0.55) | ACHECCR3ABL1RIN1 | |
| SCHEMBL7810400 | 0.78 | ABL1 (0.56) | ACHEABL1RIN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3156656 | 0.78 | ABL1 (0.56) | ACHEABL1RIN1 | |
| SCHEMBL5980555 | 0.78 | ACHE (0.54) | ACHEHTR2ACCR3ABL1RIN1 | |
| SCHEMBL7775686 | 0.78 | ACHE (0.54) | ACHEHTR2ACCR3ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703908-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5461047-A | Analgesics and treats prostaglandin-E2 mediated diseases in animals | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| WO-1994029286-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5354747-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-10-11 | — | — | US | disclosed |