Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | RAB9A | P51151 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435873 | 0.89 | MAPT (0.69) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL15348502 | 0.89 | RAB9A (0.62) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL2115567 | 0.88 | MAPT (0.64) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL1246735 | 0.87 | RAB9A (0.64) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL2838513 | 0.85 | RAB9A (0.62) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL2838509 | 0.85 | RAB9A (0.62) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL1513053 | 0.84 | RAB9A (0.60) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL2141599 | 0.84 | RAB9A (0.60) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL348057 | 0.84 | RAB9A (0.60) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 | |
| SCHEMBL15359481 | 0.84 | RAB9A (0.60) | MAPTRAB9ANPC1HSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |