Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 1.00 |
| ▸ | F3 | P13726 | 7/20 | 1.00 |
| ▸ | DRD2 | P14416 | 8/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.79 |
| ▸ | DRD4 | P21917 | 2/20 | 0.79 |
| ▸ | DRD5 | P21918 | 2/20 | 0.79 |
| ▸ | DRD3 | P35462 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | HTR1A | P08908 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29362441 | 1.00 | DRD1 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| SCHEMBL30287606 | 1.00 | DRD1 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| SCHEMBL30000536 | 1.00 | DRD1 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| SCHEMBL910461 | 1.00 | DRD1 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL3319790 | 0.99 | DRD1 (0.98) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL3319787 | 0.99 | DRD1 (0.98) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Tetrahydroberberine SCHEMBL232164 | 0.88 | F3 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Tetrahydroberberine SCHEMBL2786492 | 0.88 | F3 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Tetrahydroberberine SCHEMBL30484836 | 0.88 | F3 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 | |
| Tetrahydroberberine SCHEMBL30302597 | 0.88 | F3 (1.00) | DRD1F3DRD2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111544580-B | Anti-cancer pharmaceutical composition | 中国农业科学院北京畜牧兽医研究所 | 2021-05-28 | — | — | CN | claimed |
| CN-111544580-A | Anti-cancer pharmaceutical composition | 中国农业科学院北京畜牧兽医研究所 | 2020-08-18 | — | — | CN | claimed |
| CN-109232557-A | A kind of 9-O- aryl replaces the synthesis and purposes of berberinc derivate | 常州大学 | 2019-01-18 | — | — | CN | claimed |
| CN-106890190-A | A kind of preparation of new component with arsenic trioxide composition and purposes | 江西中医药大学 | 2017-06-27 | — | — | CN | claimed |
| US-20160340704-A1 | METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE | CONCORDIA UNIVERSITY (CA) | 2016-11-24 | — | — | US | claimed |
| WO-2015103711-A1 | METHOD OF MAKING A BENZYLISOQUINOLINE ALKALOID (BIA) METABOLITE, ENZYMES THEREFORE | Valorbec Société en Commandite (CA) | 2015-07-16 | — | — | WO | claimed |
| CN-104478888-A | Method for extracting O-methyl nandinine from Nandina domestica | SHAANXI JIAHE PHYTOCHEM CO LTD | 2015-04-01 | — | — | CN | claimed |
| CN-103450187-A | Tetrahydro-berberrubine derivative and preparation method and application thereof | HUZHOU TEACHERS COLLEGE | 2013-12-18 | — | — | CN | claimed |
| CN-102002081-B | 9-O-beta-D-glucosyl nandinine as well as preparation method and application thereof | UNIV CHINA PHARMA | 2013-04-10 | — | — | CN | claimed |
| CN-101972252-B | Application of Tetrahydroberbeine berberrubine in preparing drug for resisting anxiety and depression | INST BASIC MED SCIENCES PLA | 2012-10-10 | — | — | CN | claimed |
| CN-102702189-A | Application of silica gel in purifying process of tetrahydro berberrubine | UNIV CHINA PHARMA | 2012-10-03 | — | — | CN | claimed |
| CN-102000074-A | Application of tetrahydroberberrubine in preparation of medicines for curing schizophrenia | INST BASIC MED SCIENCES PLA | 2011-04-06 | — | — | CN | claimed |
| CN-102002081-A | 9-O-beta-D-glucosyl nandinine as well as preparation method and application thereof | UNIV CHINA PHARMA | 2011-04-06 | — | — | CN | claimed |
| CN-101972252-A | Application of Tetrahydroberbeine berberrubine in preparing drug for resisting anxiety and depression | INST BASIC MED SCIENCES PLA | 2011-02-16 | — | — | CN | claimed |
| CN-101094698-A | Biocompatible, biostable coating of medical surfaces | HEMOTEQ GMBH (DE) | 2007-12-26 | — | — | CN | claimed |
| JP-8209123-A | — | — | None | — | — | JP | disclosed |
| JP-8209123-A | — | — | None | — | — | JP | disclosed |
| CN-1961944-A | Chinese medicinal composition for treating cough and asthma | UNIV SHANGHAI OF T C M (CN) | 2007-05-16 | — | — | CN | disclosed |
| JP-H08209123-A | ANTIOXIDANT CONTAINING SCOULERINE OR NANDININE | TOPPAN PRINTING CO LTD | 1996-08-13 | — | — | JP | disclosed |
| JP-H08209123-A | ANTIOXIDANT CONTAINING SCOULERINE OR NANDININE | TOPPAN PRINTING CO LTD | 1996-08-13 | — | — | JP | disclosed |