Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.66 |
| ▸ | RARG | P13631 | 14/20 | 0.66 |
| ▸ | RXRA | P19793 | 14/20 | 0.66 |
| ▸ | RARA | P10276 | 10/20 | 0.66 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | MTOR | P42345 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051275 | 1.00 | RARB (0.66) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL31191741 | 1.00 | RARB (0.66) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL9051287 | 1.00 | RARB (0.66) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL31191744 | 0.84 | RARG (0.48) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL6511837 | 0.82 | RXRA (0.65) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL29816275 | 0.82 | RXRA (0.65) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL4587206 | 0.82 | RXRA (0.65) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL7949412 | 0.81 | RXRA (0.71) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL29836848 | 0.80 | RARB (1.00) | RARBRARGRXRARARACYP26A1 | |
| SCHEMBL345071 | 0.80 | RARB (1.00) | RARBRARGRXRARARACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11911356-B2 | Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | claimed |
| US-20200323805-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | THE JOHNS HOPKINS UNIVERSITY | 2020-10-15 | — | — | US | claimed |
| US-20240366544-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | UNIV JOHNS HOPKINS (US) | 2024-11-07 | — | — | US | disclosed |
| US-11911356-B2 | Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | disclosed |
| US-20200323805-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | THE JOHNS HOPKINS UNIVERSITY | 2020-10-15 | — | — | US | disclosed |
| WO-1995033745-A9 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | — | 1996-01-18 | — | — | WO | disclosed |
| WO-1995033745-A2 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | SRI INTERNATIONAL (US) | 1995-12-14 | — | — | WO | disclosed |