Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048727 | 0.87 | ALOX5 (0.50) | ALOX5LMNAMAPT | |
| SCHEMBL9049465 | 0.87 | ALOX5 (0.50) | ALOX5LMNAMAPT | |
| SCHEMBL9075981 | 0.87 | ALOX5 (0.50) | ALOX5LMNAMAPT | |
| SCHEMBL9272569 | 0.85 | ALOX5 (0.51) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9272567 | 0.85 | ALOX5 (0.51) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9048284 | 0.83 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL9046831 | 0.81 | ALOX5 (0.38) | ALOX5 | |
| SCHEMBL9085434 | 0.81 | ALOX5 (0.42) | ALOX5 | |
| SCHEMBL9049501 | 0.81 | HPGD (0.47) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9074258 | 0.79 | ALOX5 (0.41) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |