Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167010 | 0.86 | ACE (0.60) | ACEKMT2AL3MBTL1MAPK1F2 | |
| SCHEMBL9051863 | 0.83 | MAPK1 (0.58) | ACEKMT2AATMMAPK1F2 | |
| SCHEMBL6171028 | 0.83 | ACE (0.64) | ACEKMT2AMAPK1F2PRSS1 | |
| SCHEMBL6171025 | 0.83 | ACE (0.64) | ACEKMT2AMAPK1F2PRSS1 | |
| SCHEMBL5820675 | 0.82 | CTSS (0.57) | ACEKMT2AATMMAPK1KLK5 | |
| SCHEMBL5820678 | 0.82 | CTSS (0.57) | ACEKMT2AATMMAPK1KLK5 | |
| SCHEMBL3692085 | 0.82 | ACE (0.77) | ACEKMT2AF2PRSS1KLK5 | |
| SCHEMBL22409423 | 0.82 | ACE (0.77) | ACEKMT2AF2PRSS1KLK5 | |
| SCHEMBL3692081 | 0.82 | ACE (0.77) | ACEKMT2AF2PRSS1KLK5 | |
| SCHEMBL5900836 | 0.82 | ACE (0.77) | ACEKMT2AF2PRSS1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |