Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635846 | 1.00 | GBA1 (0.40) | GBA1GAAMGAMBRD4TDP1 | |
| Hydrochloric Acid SCHEMBL15463590 | 0.97 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| Hydrochloric Acid SCHEMBL15463591 | 0.97 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| SCHEMBL24043063 | 0.89 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| SCHEMBL13116329 | 0.87 | GBA1 (0.34) | GBA1GAAMGAM | |
| SCHEMBL18975425 | 0.86 | GBA1 (0.50) | GBA1GAAMGAM | |
| SCHEMBL19087104 | 0.84 | — | — | |
| SCHEMBL7022461 | 0.84 | — | — | |
| SCHEMBL7403991 | 0.84 | — | — | |
| SCHEMBL7020593 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996007656-A1 | CIS-HEXAHYDRO-5-(2-NAPHTHALENYL)PYRROLO<3,4-c>PYRROLES | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5457121-A | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |