Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MGAM | O43451 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052252 | 1.00 | GBA1 (0.40) | GBA1GAAMGAMBRD4TDP1 | |
| Hydrochloric Acid SCHEMBL15463590 | 0.97 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| Hydrochloric Acid SCHEMBL15463591 | 0.97 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| SCHEMBL24043063 | 0.89 | GBA1 (0.39) | GBA1GAAMGAMBRD4 | |
| SCHEMBL13116329 | 0.87 | GBA1 (0.34) | GBA1GAAMGAM | |
| SCHEMBL18975425 | 0.86 | GBA1 (0.50) | GBA1GAAMGAM | |
| SCHEMBL19087104 | 0.84 | — | — | |
| SCHEMBL7022461 | 0.84 | — | — | |
| SCHEMBL7403991 | 0.84 | — | — | |
| SCHEMBL7020593 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-04 | — | — | US | disclosed |
| US-9181277-B2 | Aminoquinazoline derivatives and their salts and methods of use | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20140228361-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-08-14 | — | — | US | disclosed |
| EP-0731090-B1 | Process for the production of 3,(4)-substituted pyrrolidines | BAYER MATERIALSCIENCE AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| EP-0499873-B1 | Use of 3,(4)-substituted pyrrozidines as catalysts in the polyisocyanate-polyaddition process and a process for the preparation of polyurethanes and polyureas | BAYER AG (DE) | 2000-11-22 | — | — | EP | disclosed |
| EP-0731090-A2 | Process for the production of 3,(4)-substituted pyrrolidines | BAYER AG (DE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1996007656-A1 | CIS-HEXAHYDRO-5-(2-NAPHTHALENYL)PYRROLO<3,4-c>PYRROLES | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5457121-A | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5274114-A | Preparation and use of 3, (4)-substituted pyrrolidines as catalysts for the polyisocyanate polyaddition process | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0499873-A2 | Use of 3,(4)-substituted pyrrozidines as catalysts in the polyisocyanate-polyaddition process, process for their preparation and a process for the preparation of polyurethanes and polyureas | BAYER AG (DE) | 1992-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228361-A1 | AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE | ABL1, PRKDC, JAK2 | GBA1 3542/4885GAA 2728/4885MGAM 4674/4885 |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | TOP1, TOP2A, TOP2B | GBA1 738/4885GAA 85/4885MGAM 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.