Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.49 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.49 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 7/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000443 | 0.83 | MAPT (0.55) | RAB9A | |
| SCHEMBL31644088 | 0.80 | SLC6A4 (0.66) | SLC6A4CCR5USP28USP25LMNA | |
| SCHEMBL368071 | 0.80 | SLC6A4 (0.66) | SLC6A4CCR5USP28USP25LMNA | |
| SCHEMBL15754442 | 0.78 | MRGPRX4 (0.56) | PTGER1RAB9A | |
| SCHEMBL24697571 | 0.78 | CCR5 (0.51) | SLC6A4CCR5USP28USP25LMNA | |
| SCHEMBL1447864 | 0.77 | SLC6A4 (0.59) | SLC6A4CCR5USP28USP25CYP1A2 | |
| SCHEMBL30504080 | 0.77 | SLC6A4 (0.59) | SLC6A4CCR5USP28USP25CYP1A2 | |
| SCHEMBL8162883 | 0.77 | CCR5 (0.54) | SLC6A4CCR5USP28USP25LMNA | |
| SCHEMBL6762763 | 0.76 | PTPN1 (0.41) | CCR5LMNAHTTPTGER1ALDH1A1 | |
| SCHEMBL3724781 | 0.76 | CCR5 (0.66) | CCR5USP28USP25LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996003380-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1996-02-08 | — | — | WO | disclosed |