Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626831 | 0.86 | MAPT (0.72) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL29769924 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL28780405 | 0.86 | MAPT (0.72) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL30682399 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL6855264 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL30912053 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL30912054 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL13790109 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL6278978 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL29043130 | 0.84 | MAPT (0.70) | SMN1; SMN2MAPTKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719777-A2 | N-oxotetrahydro-beta-carbolines | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1996-07-03 | — | — | EP | disclosed |
| US-5348949-A | Method of preparing N-oxo-tetrahydro-β-carbolines | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1994-09-20 | — | — | US | disclosed |
| US-5106840-A | Cyclization of substituted indoles | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-04-21 | — | — | US | disclosed |
| EP-0401929-A2 | Method of preparing N-oxotetrahydro- -carbolines | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-12-12 | — | — | EP | disclosed |