Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972200 | 0.97 | AGTR1 (0.44) | AGTR1AGTR2TLR7 | |
| SCHEMBL8972313 | 0.97 | AGTR1 (0.44) | AGTR1AGTR2TLR7 | |
| SCHEMBL8971906 | 0.88 | PDE10A (0.41) | AGTR1AGTR2 | |
| SCHEMBL9311939 | 0.86 | TLR7 (0.39) | AGTR1AGTR2TLR7 | |
| SCHEMBL8972044 | 0.85 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL8565215 | 0.84 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL8971527 | 0.84 | AGTR1 (0.37) | AGTR1AGTR2 | |
| Ammonia Solution, Strong SCHEMBL9053252 | 0.84 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL8972563 | 0.84 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL8563430 | 0.83 | AGTR1 (0.38) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420237-B1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | EISAI CO LTD (JP) | 1996-03-06 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |