Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.86 |
| ▸ | POLB | P06746 | 3/20 | 0.86 |
| ▸ | MEN1 | O00255 | 3/20 | 0.86 |
| ▸ | GAA | P10253 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29963082 | 1.00 | KMT2A (0.86) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL2762197 | 0.93 | GAA (1.00) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL29963500 | 0.93 | GAA (1.00) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL21843254 | 0.85 | ALDH1A1 (1.00) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL29373128 | 0.85 | ALDH1A1 (1.00) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL9098061 | 0.79 | KMT2A (0.61) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL9097140 | 0.75 | KMT2A (0.67) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL5314641 | 0.75 | KMT2A (0.67) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL9097528 | 0.75 | KMT2A (0.67) | KMT2APOLBMEN1GAAMAPK1 | |
| SCHEMBL2780325 | 0.75 | KMT2A (0.67) | KMT2APOLBMEN1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115991693-A | Coumarin-containing compound and preparation method and application thereof | 华东理工大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-115368349-A | Novel N-substituted isatin derivative, preparation thereof and application thereof in preparation of antitumor drugs | 中国医学科学院药用植物研究所 | 2022-11-22 | — | — | CN | disclosed |
| CN-115340495-A | O-nitrobenzene compound and preparation method and application thereof | 华东理工大学 | 2022-11-15 | — | — | CN | disclosed |
| CN-115124487-A | Preparation method and application of arylimino thiazole compounds | 华东理工大学 | 2022-09-30 | — | — | CN | disclosed |
| CN-108276352-B | Nitrogen-containing heterocyclic compound with nematicidal activity and preparation method and application thereof | 华东理工大学 | 2022-09-20 | — | — | CN | disclosed |
| CN-114105986-A | Aromatic condensed ring diketone compound and preparation method and application thereof | 华东理工大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-107625766-B | Application of thiazole compound as antibacterial synergist | 上海医药工业研究院 | 2021-08-31 | — | — | CN | disclosed |
| CN-113150053-A | Azobenzene avermectin derivative and preparation method and application thereof | 华东理工大学 | 2021-07-23 | — | — | CN | disclosed |
| CN-104530037-B | Triazine heterocyclic compound with nematicidal activity and preparation method and application thereof | 华东理工大学 | 2020-12-18 | — | — | CN | disclosed |
| CN-111518022-A | Aromatic (hetero) cyclic ether compound with insecticidal activity and preparation method and application thereof | 华东理工大学 | 2020-08-11 | — | — | CN | disclosed |
| US-9073935-B2 | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 | VANDERBILT UNIVERSITY (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073935-B2 | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 | VANDERBILT UNIVERSITY (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073935-B2 | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 | VANDERBILT UNIVERSITY (US) | 2015-07-07 | — | — | US | disclosed |
| WO-2013071201-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2013-05-16 | — | — | WO | disclosed |
| US-20130123236-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123236-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123236-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2013071201-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2013-05-16 | — | — | WO | disclosed |
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123236-A1 | SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 | CHRM1, CHRM2, CHRM3 | KMT2A 1250/4885POLB 4506/4885MEN1 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.