Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631906 | 0.98 | TSHR (0.62) | TSHREPHX2ADRA1APRMT1RECQL | |
| SCHEMBL28440634 | 0.96 | TSHR (0.64) | TSHREPHX2ADRA1APRMT1RECQL | |
| SCHEMBL13376980 | 0.91 | RECQL (0.61) | TSHREPHX2RECQLLMNAL3MBTL1 | |
| SCHEMBL2771342 | 0.89 | RECQL (0.63) | TSHREPHX2RECQLLMNAL3MBTL1 | |
| SCHEMBL15399777 | 0.89 | TSHR (0.65) | TSHREPHX2RECQLLMNAL3MBTL1 | |
| SCHEMBL13405232 | 0.87 | TSHR (0.53) | TSHREPHX2ADRA1APRMT1RECQL | |
| SCHEMBL16620817 | 0.87 | RECQL (0.61) | TSHREPHX2RECQLLMNAL3MBTL1 | |
| SCHEMBL28757328 | 0.87 | PRMT1 (0.68) | TSHREPHX2ADRA1APRMT1LMNA | |
| SCHEMBL24483715 | 0.85 | PRMT1 (0.71) | TSHREPHX2ADRA1APRMT1LMNA | |
| SCHEMBL22506195 | 0.85 | PRMT1 (0.71) | TSHREPHX2ADRA1APRMT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264065-B1 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK AS (DK) | 2017-03-08 | — | — | EP | disclosed |
| US-20140349925-A1 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK AS (DK) | 2014-11-27 | — | — | US | disclosed |
| US-8828923-B2 | Insulin derivatives | NOVO NORDISK A/S (DK) | 2014-09-09 | — | — | US | disclosed |
| EP-2275439-B1 | Novel insulin derivatives | NOVO NORDISK AS (DK) | 2014-03-26 | — | — | EP | disclosed |
| EP-2107069-B1 | Novel insulin derivatives | NOVO NORDISK AS (DK) | 2013-01-16 | — | — | EP | disclosed |
| EP-2287184-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2011-02-23 | — | — | EP | disclosed |
| EP-2275439-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2011-01-19 | — | — | EP | disclosed |
| EP-2264065-A2 | Novel Insulin Derivatives | NOVO NORDISK A/S (DK) | 2010-12-22 | — | — | EP | disclosed |
| EP-2264066-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2010-12-22 | — | — | EP | disclosed |
| US-20100009899-A1 | Novel Insulin Derivatives | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| US-7615532-B2 | Antidiabetic agents; insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the alpha-amino group of the N-terminal amino acid residue of the B chain or to epsilon-amino group of a Lys residue present in the B chain of parent insulin | NOVO NORDISK A/S (DE) | 2009-11-10 | — | — | US | disclosed |
| EP-2107069-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2009-10-07 | — | — | EP | disclosed |
| US-20060183668-A1 | Antidiabetic agents; insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the alpha-amino group of the N-terminal amino acid residue of the B chain or to epsilon-amino group of a Lys residue present in the B chain of parent insulin | NOVO NORDISK A/S (DK) | 2006-08-17 | — | — | US | disclosed |
| EP-1660531-A2 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005012347-A2 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2005-02-10 | — | — | WO | disclosed |