Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666089 | 0.89 | TSHR (0.62) | TSHREPHX2KDM4EADRA1ASMN1; SMN2 | |
| SCHEMBL12666182 | 0.89 | TSHR (0.62) | TSHREPHX2KDM4EADRA1ASMN1; SMN2 | |
| SCHEMBL18631906 | 0.89 | TSHR (0.62) | TSHREPHX2RECQLKDM4EADRA1A | |
| SCHEMBL905401 | 0.87 | TSHR (0.66) | TSHREPHX2RECQLKDM4EADRA1A | |
| SCHEMBL28440634 | 0.87 | TSHR (0.64) | TSHREPHX2RECQLKDM4EADRA1A | |
| SCHEMBL16500463 | 0.86 | SMN1; SMN2 (0.58) | TSHREPHX2KDM4EADRA1ASMN1; SMN2 | |
| SCHEMBL22562632 | 0.86 | EPHX2 (0.60) | TSHREPHX2RECQLKDM4EALDH1A1 | |
| SCHEMBL15503378 | 0.86 | SMN1; SMN2 (0.58) | TSHREPHX2KDM4EADRA1ASMN1; SMN2 | |
| SCHEMBL14118056 | 0.86 | EPHX2 (0.60) | TSHREPHX2RECQLKDM4EALDH1A1 | |
| SCHEMBL12733522 | 0.86 | TSHR (0.67) | TSHREPHX2KDM4EADRA1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700560-B2 | Inactivators and bivalent inhibitors of glyoxalase I and methods of inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY (US) | 2010-04-20 | — | — | US | disclosed |
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | UNIVERSITY OF MARYLAND, BALTIMORE COUNTY | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129311-A1 | Inactivators and bivalent inhibitors of glyoxalase i and methods inhibiting tumor growth | GLS, GLO1, GLRX3 | TSHR 3314/4885EPHX2 163/4885RECQL 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.