Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559567 | 0.81 | HDAC8 (0.48) | HDAC8LOXL2HRH3 | |
| SCHEMBL12009961 | 0.77 | CHRNB2 (0.45) | HTR6POLB | |
| SCHEMBL2006349 | 0.77 | CHRNB2 (0.45) | HTR6POLB | |
| SCHEMBL2009217 | 0.77 | CHRNB2 (0.45) | — | |
| SCHEMBL2009034 | 0.77 | CHRNB2 (0.45) | — | |
| SCHEMBL2010528 | 0.77 | CHRNB2 (0.45) | — | |
| SCHEMBL2005748 | 0.77 | CHRNB2 (0.45) | HTR6POLB | |
| SCHEMBL2005746 | 0.77 | CHRNB2 (0.45) | HTR6POLB | |
| SCHEMBL26054231 | 0.76 | BCHE (0.53) | HDAC8LOXL2HRH3 | |
| SCHEMBL12009958 | 0.73 | CHRNB2 (0.40) | HTR6POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695301-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-02-07 | — | — | EP | disclosed |