Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6143586 | 0.82 | CYP26A1 (0.53) | SSTR5AKR1B1CYP26A1CYP26B1MAPT | |
| SCHEMBL6017351 | 0.81 | SSTR5 (0.42) | SSTR5AKR1B1CYP26A1CYP26B1MAPT | |
| SCHEMBL27259756 | 0.78 | AKR1B1 (0.43) | SSTR5AKR1B1CYP26A1CYP26B1FTO | |
| SCHEMBL8864966 | 0.77 | CYP3A4 (0.40) | SSTR5AKR1B1CYP26A1CYP26B1BACE1 | |
| SCHEMBL3550976 | 0.77 | RARB (0.47) | CYP26A1CYP26B1BACE1 | |
| SCHEMBL4518818 | 0.75 | BACE1 (0.51) | SSTR5AKR1B1MAPTCTSDBACE1 | |
| SCHEMBL9054260 | 0.75 | MAPT (0.42) | SSTR5AKR1B1MAPTCTSDBACE1 | |
| SCHEMBL2246604 | 0.74 | CYP26A1 (0.51) | SSTR5AKR1B1CYP26A1CYP26B1 | |
| SCHEMBL11358788 | 0.73 | CNR2 (0.38) | CNR2CNR1ALOX15ALOX12MAPT | |
| SCHEMBL29228926 | 0.73 | HIF1A (0.44) | SSTR5MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |