Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 6/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.49 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737195 | 0.86 | CYP26A1 (0.47) | CYP26A1CYP26B1AKR1B1SSTR5RXRA | |
| SCHEMBL5736766 | 0.82 | CYP26B1 (0.48) | CYP26A1CYP26B1AKR1B1SSTR5RXRA | |
| SCHEMBL9054884 | 0.82 | SSTR5 (0.43) | CYP26A1CYP26B1AKR1B1SSTR5KDM4E | |
| SCHEMBL8876189 | 0.81 | CYP26A1 (0.43) | CYP26A1CYP26B1AKR1B1SSTR5 | |
| SCHEMBL6017351 | 0.79 | SSTR5 (0.42) | CYP26A1CYP26B1AKR1B1SSTR5MAPT | |
| SCHEMBL17316518 | 0.79 | CYP26A1 (0.52) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL6144438 | 0.79 | CYP26A1 (0.58) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL5736575 | 0.78 | SSTR5 (0.50) | CYP26A1CYP26B1AKR1B1SSTR5RXRA | |
| SCHEMBL13613854 | 0.77 | AKR1B1 (0.47) | CYP26A1CYP26B1AKR1B1SSTR5RXRA | |
| SCHEMBL6146899 | 0.77 | CYP26A1 (0.69) | CYP26A1CYP26B1AKR1B1SSTR5RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1293034-C | New gamma selective retinoids | HOFFMANN LA ROCHE (CH) | 2007-01-03 | — | — | CN | disclosed |
| EP-1280757-B1 | NEW GAMMA SELECTIVE RETINOIDS | HOFFMANN LA ROCHE (CH) | 2005-08-17 | — | — | EP | disclosed |
| US-6603012-B2 | RAR selective retinoid agonists | HOFFMANN-LA ROCHE INC. | 2003-08-05 | — | — | US | disclosed |
| CN-1430596-A | New gamma selective retinoids | HOFFMANN LA ROCHE (CH) | 2003-07-16 | — | — | CN | disclosed |
| EP-1280757-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-05 | — | — | EP | disclosed |
| US-20020026060-A1 | RAR selective retinoid agonists | F.HOFFMANN-LA ROCHE AG (CH) | 2002-02-28 | — | — | US | disclosed |
| WO-2001083438-A2 | NEW GAMMA SELECTIVE RETINOIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020026060-A1 | RAR selective retinoid agonists | RARA, RARG, RARB | CYP26A1 474/4885CYP26B1 923/4885AKR1B1 863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.