⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22750778 | 0.78 | — | — | |
| SCHEMBL4258347 | 0.67 | — | — | |
| SCHEMBL23893212 | 0.66 | — | — | |
| SCHEMBL444554 | 0.65 | — | — | |
| SCHEMBL632731 | 0.65 | — | — | |
| SCHEMBL18884434 | 0.63 | — | — | |
| SCHEMBL4215210 | 0.62 | — | — | |
| SCHEMBL5423678 | 0.62 | — | — | |
| Cyanamide SCHEMBL28089099 | 0.62 | ALDH1A1 (0.35) | — | |
| Hydrochloric Acid SCHEMBL11396954 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107075498-A | Selective advantage in fermentation | 诺沃吉公司 | 2017-08-18 | — | — | CN | claimed |
| US-20240276957-A1 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. | 2024-08-22 | — | — | US | disclosed |
| CN-114174288-A | Methods of treatment with aminolevulinic acid synthase 2(ALAS2) modulators | 安吉奥斯医药品有限公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| CN-109293551-A | Method and composition relevant to granulocyte colony stimulating factor receptor | 利亘制药公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-107075498-A | Selective advantage in fermentation | 诺沃吉公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104039761-A | Methods and compositions related to granulocyte colony stimulating factor receptor | LIGAND PHARM INC | 2014-09-10 | — | — | CN | disclosed |
| CN-102712625-B | Nitrogen-containing heteroaryl derivatives | HOFFMANN LA ROCHE | 2014-04-09 | — | — | CN | disclosed |
| CN-103214460-A | Chemical compounds | SYNGENTA PARTICIPATIONS AG | 2013-07-24 | — | — | CN | disclosed |
| CN-102753184-A | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases | SANOFI AVENTIS | 2012-10-24 | — | — | CN | disclosed |
| CN-1964984-A | Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-05-16 | — | — | CN | disclosed |
| CN-1914205-A | Pyrazolo [3, 4-b ] pyridine compounds and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | CN | disclosed |
| CN-1791611-A | 17beta-hydroxysteroid dehydrogenase inhibitors. | STERIX LTD (GB) | 2006-06-21 | — | — | CN | disclosed |
| CN-1751042-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2006-03-22 | — | — | CN | disclosed |
| CN-1694882-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2005-11-09 | — | — | CN | disclosed |
| CN-1149085-C | Inhibition of RAF kinase with substituted heterocyclic ureas | — | 2004-05-12 | — | — | CN | disclosed |
| CN-1148346-C | Hydrazine derivative | - | 2004-05-05 | — | — | CN | disclosed |
| CN-1309634-A | Hydrazine derivs. | HOFFMANN LA ROCHE (CH) | 2001-08-22 | — | — | CN | disclosed |
| CN-1290164-A | Inhibition of RAF kinase with substituted heterocyclic ureas | BAYER AG (US) | 2001-04-04 | — | — | CN | disclosed |
| WO-1996012706-A1 | NOVEL ACID PYRAZOLE AND PYRAZOLONE DERIVATIVES FOR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1996-05-02 | — | — | WO | disclosed |